Atorvastatin Tablets

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Therapeutic Indication

Hypercholesterolemia
Mixed dyslipidemia
Prevention of cardiovascular diseases
Reduction of LDL cholesterol
Prevention of stroke and heart attack
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Atorvastatin

Tablet

Atorvastatin Tablets belong to the statin class of medications used to lower cholesterol levels in the blood. It works by inhibiting cholesterol synthesis in the liver, thereby reducing LDL (bad cholesterol) and triglycerides while increasing HDL (good cholesterol). This helps in preventing cardiovascular diseases such as heart attack, stroke, and atherosclerosis.

Speciality HMG-CoA Reductase Inhibitor
Tags Cardiac Care | Lipid Control
Strength
  • 10 mg
  • 20 mg
  • 40 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Atorvastatin inhibits the enzyme HMG-CoA reductase, which plays a key role in cholesterol biosynthesis in the liver. This results in decreased cholesterol production and increased uptake of LDL cholesterol from the bloodstream.

Pharmacodynamics

It reduces total cholesterol, LDL cholesterol, and triglycerides while modestly increasing HDL cholesterol, thereby improving overall lipid profile and reducing cardiovascular risk.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration
  • Bioavailability: Approximately 14%
  • Peak Plasma Time: 1–2 hours
  • Protein Binding: >98%
  • Metabolism: Extensively metabolized in liver via CYP3A4
  • Half-life: ~14 hours (active metabolites up to 30 hours)
  • Excretion: Mainly via bile; minimal renal elimination

Side Effects

  • Headache
  • Muscle pain (myalgia)
  • Abdominal pain
  • Nausea
  • Elevated liver enzymes

Contraindication

  • Active liver disease
  • Pregnancy and lactation
  • Hypersensitivity to atorvastatin

Interaction

  • Cyclosporine
  • Fibrates (increased risk of myopathy)
  • Anticoagulants
  • Grapefruit juice (increases drug levels)

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

  • Monitor liver function tests regularly
  • Risk of muscle toxicity (myopathy/rhabdomyolysis)
  • Use cautiously in liver impairment
  • Avoid alcohol consumption

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.